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OPENING NEW DIVISION - CENTER OF REFERENCE FOR THE CARE OF REGIONAL OSP-thalassemia. SANT 'EUGENIO ROME


Professor Paolo Cianciulli, and the actress Tosca D'Aquino Day dell'innaugurazione DH Department of thalassemia Osp. Eugene Rome

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ADMO Association of Bone Marrow Donors


Milan, 26 November - One of the important birthdays of our Italy, this year there is a very special IBMDR twenties, the Italian registry of donors bone marrow, which since 1989 has managed to turn the goodwill of a handful of researchers, doctors and Italian volunteers in international excellence.

The numbers are always some effect, especially when lives are reported to continue or end. In 1989

voluntary donors on the register - which is based at the Galliera Hospital in Genoa - were 2500 and in 2009 the figure was over 370,000 donors, and potential.

Thanks to all those men and women of good will that many (and unfortunately growing) people admitted to hospital to treat serious diseases and blood cancers (leukemia, lymphoma, myeloma, thalassemia) can have a hope of making it more .

Yet, although the bone marrow donors have reached a substantial figure, this figure is not enough.

salt is not enough because the number of people needing a transplant. It is not enough, for patients who have a sibling donor, hoping to find a compatible bone marrow is dependent on the largest possible number of volunteer donors so-called 'typed', that is already familiar with genetic characteristics, and registered in a special database.

compatibility between unrelated, in fact, a frightening proportion: only 1 in 100,000! For this reason

IBMDR of Genoa is connected with the registers of all the world, because every time it is needed, the search for the donor is activated anywhere.

To inform and sensitize the population, then 28 and returns Nov. 29 in the Italian squares ADMO the initiative 'a cake for life'. Faced with an offer to all people of good will is given a cake.

Most importantly, these same people of good will the volunteers of the Bone Marrow Donors are ready to give any information about their donation and to resolve any doubt or fear.

Abruzzo ADMO volunteers will be present:

Avezzano (AQ), Piazza Risorgimento - Saturday 28 and Sunday, November 29.
BARREA (AQ) Main Square - Sunday, November 29.
Castel di Sangro (AQ), Piazza Plebiscito, porches Pro Loco - Sunday, December 6.
Magliano de 'Marsi (AQ) Piazza della Repubblica - Sunday, November 29 10.00 - 13.00.
Sulmona (AQ), Corso Ovidio front of Bar Europa - Saturday, November 28.
Pescara, Piazza Lounge - Saturday 28 and Sunday, November 29 10.30 - 14.00 -
PEOPLE (PE) - Piazza Paolini - Saturday 28 and Sunday, November 29. CASOLI of Chieti (CH), Corso Umberto - Saturday 28 and Sunday, November 29 in the afternoon.
Lanciano (CH), Piazza Plebiscito and Corso Trento e Trieste before BNL - Saturday 28 and Sunday, November 29.
Roccamontepiano (CH), Parish of St. Rocco - Piazza San Rocco - Saturday 28 and Sunday, November 29.
Faron (TE), Parish - Saturday 28 and Sunday, November 29. Garrufo OF S. OMERO (TE), Parish - Saturday 28 and Sunday, November 29.
Paolantonio (TE), Parish - Saturday 28 and Sunday, November 29. S. EGIDIO TO VIBRATA (TE), Parish - Saturday 28 and Sunday, November 29.
Torano Nuovo (TE), Parish - Saturday 28 and Sunday, November 29


To know the squares of life you can call ADMO (02 39000855) or go to www.admo.it

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The transplantation of stem cells

F. F. Locatelli
A. Moretta
Tolva
F. Introzzi
P. Merli
Pediatric Oncology,
University of Pavia, Fondazione IRCCS Policlinico

San Matteo, Pavia
Prof. Franco Locatelli,
Pediatric Oncology, Fondazione IRCCS Policlinico

San Matteo, University of
Pavia, Piazzale Golgi 2, I-27100
Pavia, Italy.
Tel:
+39-0382-502607 Fax: +39-0382-501251
E-mail: @ f.locatelli smatteo.pv.it
a family
HLA compatibile.1, 3 Through
HSCT,
a large majority of patients with thalassemia major
gained independence

transfusion and the possibility of reducing the overload of iron accumulated

with erythrocyte transfusions,
through the regular use of procedures
phlebotomist, usually taken from the three months
posttrapianto
in the presence of hemoglobin values \u200b\u200b

above 10 g / dL.
Since the early use of
HSCT, it became obvious that the results obtained through the


transplant treatment was better in subjects
pediatric rispetto ai pazienti
adulti.3-6 All’interno della popolazione
pediatrica è, altresì, stato
possibile identificare fattori prognosticamente
rilevanti in grado
di predire il rischio di complicanze
associate al TCSE e la
possibilità di beneficiare del
medesimo. Più in dettaglio, la
regolarità o meno della terapia
ferrochelante, l’assenza o la presenza
di epatomegalia, così
come di fibrosi portale alla valutazione
istologica della biopsia
epatica, hanno consentito di
stratificare i pazienti pediatrici
in tre differenti classi di rischio,
la prima delle quali prevede la
presenza di tutti e 3 i
prognostic parameters and the third

identifies the group with pre-transplant characteristics predictive of worst
andamento.1, 4

Numerous studies have allowed to identify the possibility of disease-free survival

quantifiable
of order ' 85-90% for patients belonging to the first class

risk, 80% for patients

attributable to the second class of risk and 65-70% for patients assigned to the Third

risk class, so
as for adult patients. Conversely, the mortality risk
trapiantocorrelata
increases progressively from
prima alla terza
classe di rischio e nei soggetti adulti.1,3–7
Per tanti anni, il regime di condizionamento
pre-trapianto nei soggetti affetti da talassemia
major si è basato sulla combinazione
di busulfano e ciclofosfamide. Recenti studi
indicano la possibilità di utilizzare farmaci
quali la fludarabina e il thiotepa invece della
ciclofosfamide per ridurre il rischio di tossicità
peri-trapiantologica e la conseguente
morbilità/mortalià correlata.8,9 Il treosulfano,
farmaco di ancor più recente introduzione, si
propone come valida alternativa all’uso del
busulfano e potrebbe permettere il risparmio
della fertilità dei patients undergoing HSCT
for years significantly affected by the use of busulfan
medesimo.10
immunological and biological features of
HSCT in patients with thalassemia major
is the possibility that, in a proportion of patients to quantify the order of

10-15%, will also establish a state of mixed chimerism
stable and persistent over time,
in which rates of donor hematopoiesis
no more than 20-30%
possible to obtain independence of transfusion patients
trapiantati.11 The setting
of patients exhibiting a mixed chimerism Statilia,
represents a formidable field of study for understanding the

basic mechanisms of tolerance compared to alloantigens.

elucidation of these mechanisms could provide relevant information that may
also applicable to the field of solid organ transplantation
.
For many years the application of HSCT
has been affected by the need for the patient to have a

HLA-compatible family donor, an event that occurs
only in 25-30% of cases. The establishment of registers of
voluntary donors of bone marrow
allowed to offer another significant proportion of patients

the opportunity to have access to the transplant procedure.
In particular, è oggi stimabile che un donatore
non consanguineo, identico a livello
allelico per i loci A, B, C e DRB1 del sistema
HLA, sia oggi identificabile per circa il
35-40% dei pazienti che attivano la ricerca
sui vari registri internazionali dei donatori
volontari di cellule staminali emopoietiche.8
L’impiego di metodiche di tipizzazione ad
alta risoluzione per i loci di prima e seconda
classe del sistema HLA, così come l’adozione
di stringenti criteri di istocompatibilità
nella coppia donatore ricevente, hanno permesso
di ottenere risultati in termini di guarigione
del tutto sovrapponibili a quelli
riportati grazie all’impiego di un
family donor HLA-compatibile.8, 12
The average time that elapses between the start of the search
and the execution of an unrelated donor transplant

be quantified in the order of 3-4 months and must be stressed
as it must be used instead of bone marrow stem cells from
,
procedure after mobilization from peripheral blood
to reduce the risk of developing disease

graft-versus-host (graft versus host disease, GVHD) in its form
acute or chronic.
allelic identity at the level of the DP locus of the HLA system inequalities or the presence of immunologically

permissive, proved able to reduce the risk of rejection
of tapianto
than that observed in the pairs
donor / recipient in which any differences are not immunologically
allelic
permissive.12
In recent years, the transplant
hematopoietic progenitors derived from cord blood has

represented a valuable alternative to the use of bone marrow as a source of stem cells
also in people with thalassemia.
9 In particular, the reduced alloreactivity of lymphocytes in the blood

cord is associated with a reduction
F. Locatelli et al.
Hematology Meeting Reports 2007, 1 (6) pre-implantation embryos
healthy HLA-compatible
from which you can obtain hematopoietic stem cells from umbilical cord blood at the time of
nascita.13, 14 It is, however, stressed that this procedure

is not legally feasible in our country. For
today there is no data related to a
use of cord blood from unrelated donor for the construction of kin

HSCT in patients with thalassemia major.
Finally, it must be remembered that procedures
transplantation in thalassemia patients
preceded by conditioning regimens with reduced intensity
,
not been shown to be associated with significant probability of being successful
al contrario gravate da un elevato
rischio di mancato attecchimento dell’emopoiesi
del donatore.1,15

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TRANSLATION

stem cell transplantation to help Thamirabharuni girl eight years, get rid of the fatal genetic blood disorder thalassemia. The transplant was done in March, almost 100 days after treatment of stem cells can safely say that the girl is taken care of by thalassemia.Thalassemia is an inherited disorder of the blood, passed down through families in which the body is a form abnormal hemoglobin, the protein in red blood cells that carries oxygen. The disorder results excessive destruction of red blood cells and anemia.Severe thalassemia can cause premature death due to heart failure, usually between 20 and 30 years. Frequent blood transfusion therapy to remove iron from the body helps to improve outcome.Thamirabharuni was treated with a combo package of stem cell transplantation. The transplantation of stem cells were collected from various sources of his brother a year older, a proportion of stem cells from umbilical cord, which was collected from the umbilical cord of his brother and was stored at Chennai based LifeCell International Pvt .. Ltd., a private cord blood bank and the additional requirement was also satisfied from the bone marrow of his bone marrow brother.The actual requirement was 200 ml which really has not been possible to collect a year old brother Pugazhendhi Thamirabharuni, but Fortunately, the umbilical cord was stored with LifeCell, both bone marrow and cord blood can collectively save the lives of young girl.According to Dr. Revathy Raj, consultant pediatric oncologist Haemate, special Apollo Hospital, Chennai, even though thalassemia is healed, but the patient must be very careful with regard to the risk of infection for at least a year, as you will with immuno-suppression drugs for a year to minimize the risk of rejection of transplanted stem cells and disease graft versus host (GVHD), which also needs some time to be reduced.However as the match was perfect fabric Thamirabharuni, did not have to suffer rejection or graft versus host disease.Are you are pregnant or planning to have a child in the near future? If so, then do not forget to save the cord blood of their child, it can really save a life.

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Stem cell transplant

Stem cell transplant help eight years old girl Thamirabharuni, get rid of the deadly genetic blood disorder thalassemia. The transplant was done on last March, almost 100 days after the stem cell treatment one can surely say that the girl is cured from thalassemia.Thalassemia is an inherited blood disorder passed down through families in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells and anemia.Severe thalassemia can cause early death due to heart failure a, usually between ages 20 and 30. Frequent blood transfusions with therapy to remove iron from the body helps improve the outcome.Thamirabharuni was treated with a combo package of stem cell transplant. The transplanted stem cells were collected from different sources of her one year old brother, some portion of required stem cells came from cord blood, which was harvested from the umbilical cord of her brother and was stored at Chennai based LifeCell International Pvt. Ltd., a private cord blood bank and the extra requirements was also fulfilled from the bone marrow of her brother.The actual requirement of bone marrow was 200ml which was really not possible to collect from one year old Pugazhendhi brother of Thamirabharuni, but as luckily the cord blood was stored with LifeCell, both the bone marrow and cord blood collectively able to save the life of the young girl.According to Dr. Revathy Raj, Consultant Paediatric Haemato Oncologist, Apollo Speciality Hospital, Chennai, though thalassemia is cured but the patient should be very careful regarding the risk of infection at least for a year, as she will be having immuno supressing drugs for one year to minimize the rejection risk of the transplanted stem cells and the graft versus host disease (GVHD) which also needs some time to be reduced.However, as the tissue match was perfect Thamirabharuni, did not have to suffer from rejection or graft versus host disease.Are you pregnant or planning to have a child in near future? If so, then never forget to save the umbilical cord blood of your child- it may truly save a life.

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Mismanagement, ignorance causes 7 to 10 deaths Every day two to sickle cell anemia: experts

Posted: Saturday, Jun 20, 2009 at 0118 hrs IST ArticlesMost Read Related Articles
Almost a decade needle, the Baroda Medical College (BMC) Became the first in the institute were to initiate research on the genetic disorder of sickle cell anemia, Which has affected a huge portion of tribal population in Gujarat. But in the past four years, the medical college has seen a complete stagnancy with no research Proposals in line.
In a five-year project of the Indian Council of Medical Research (ICMR), between 2000 and 2005, the BMC had initiated the project of sickle cell anaemia and Thalassemia screening in antenatal and college students.
The project was jointly funded by ICMR and the state government with Rs 75 lakh for the project and Rs 50 lakh for the infrastructure development of genetic laboratory.
However, after completion of the project, the BMC had proposed to carry out a second phase of the same project focusing on the prenatal diagnosis of sickle cell anaemia and Thalassemia. “Since this is a genetic disorder, there is a 50 per cent chance of passing on of the disease to the progeny. The aim of the project was to study the prevalence of sickle cell at the foetus level so that the genetic disorder can be detected and stopped before the birth of the infant,” said Dr R Z Patel, retired associate professor of the Pathology Department, BMC.

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Ninth Cooley's Anemia Symposium

October 21 - 24, 2009
The New York Academy of Sciences
Presented by the Cooley's Anemia Foundation and the New York Academy of Sciences
Thanks to scientific advances, individuals with thalassemia—a group of genetic blood disorders which includes Cooley's Anemia—are now living into their 40s and 50s. Not only are individuals living longer, but their quality of life has increased. Scientific and clinical advancements have resulted in new iron-chelating drugs, early detection of organ failure, an understanding of adult complications associated with living with thalassemia (osteoporosis, heart failure, growth hormone defi ciency, pulmonary hypertension, and in fertility) and promising progress towards the ultimate magic bullet—a cure in the form of bone marrow and cord blood transplants, or gene therapy.
The symposium will integrate basic science and clinical research so that both scientists and clinicians can develop a mutual understanding of recent progress in thalassemia.Patients are also welcome to attend the symposium and are eligible for discounted prices. Please email info@cooleysanemia.org or call 800. 522.7222 for more information.
The Thalassemia Action Group (TAG), the only national patient support group for thalassemia patients, will host a one-day meeting in conjunction with this conference. The meeting, to be held on Saturday October 24th from 9:00 am to 5:00 pm, is intended for patients and family members in order to educate them on presentations and scientific advancements discussed during the symposium. It is a chance for patients to hear experts on thalassemia, ask questions and discuss the concerns that face those afflicted with thalassemia. For more information please visit www.cooleysanemia.org or email info@cooleysanemia.org. For information about registration to the TAG meeting please call 800.522.7222 (ext 205)
Call for Abstracts
The deadline for abstract submissions is Friday, August 14, 2009. For complete abstract instructions, please e-mail: cooleys@nyas.org. Type the words "Abstract Information" in the subject line—there is no need to type a message. Instructions will be forwarded automatically. Any questions, please call 212.298.8681.

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TRANSLATION

Thanks to scientific progress, people with thalassemia, a group of genetic blood disorders including anemia, Cooley now live into their 40s and 50s. Not only are people living longer, but their quality of life has increased. Clinical and scientific advances have led to new iron chelating drugs, early diagnosis of organ failure, the understanding of adults living with complications associated with thalassemia (osteoporosis, heart failure, growth hormone deficiency ciency, pulmonary hypertension, and fertility) and promising progress towards the ultimate magic bullet-a cure in the form of bone marrow and cord blood transplants, or gene therapy.
The symposium will be the integration of basic science and clinical research, so that both scientists and clinicians can develop a mutual understanding of recent advances in thalassemia.Patients are also invited to attend the conference and are eligible for price rates. Info@cooleysanemia.org Please email or call 800. 522.7222 for more information.
Thalassemia Action Group (TAG), the only national patient support group for thalassemia patients, there will be a one-day meeting in conjunction with this conference. The meeting will be held on Saturday 24. October from 9:00 am to 5:00 pm, is intended for patients and families to educate their presentations on scientific advances and discussed during the symposium. This is a chance for patients to hear the expert on thalassemia, ask questions and discuss the problems faced by those affected with thalassemia. For more information, please visit or e-mail www.cooleysanemia.org info@cooleysanemia.org. For information about registering TAG meeting, please call 800.522.7222 (ext 205)

Call for Abstracts The deadline for abstract submission is Friday, August 14, 2009. For complete abstract instructions, send an e-mail: cooleys@nyas.org. Key words "Abstract Information" in the subject line, do not need to type a message. User manual will be sent automatically. Any questions, please call 212.298.8681.

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TRANSLATION :

Almost a decade ago, the Baroda Medical College (BMC) has become the first institution was to initiate research into genetic disorders of sickle cell disease, which affected a large portion of tribal population in Gujarat. But in the last four years, the medical college has seen a complete stagnancy without research proposals in line. In a period of five years of the project, the Indian Council of Medical Research (ICMR), between 2000 and 2005, the BMC began the project of sickle cell anemia and thalassemia screening prenatali e studenti universitari.

Il progetto è stato finanziato congiuntamente da ICMR e il governo statale con Rs 75 lakh per il progetto e Rs 50 lakh per lo sviluppo delle infrastrutture di laboratorio di genetica. Tuttavia, dopo il completamento del progetto, la BMC aveva proposto di procedere ad una seconda fase dello stesso progetto, incentrata sulla diagnosi prenatale di anemia falciforme e la talassemia. "Poiché si tratta di un disordine genetico, c'è un 50 per cento di possibilità di trasmettere la malattia alla progenie. L'obiettivo del progetto era quello di studiare la prevalenza di falce cella al feto livello in modo che il disordine genetico possono essere individuati e fermati

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Mismanagement, ignorance causes 7 to 10 deaths Every day two to sickle cell anemia: experts

Posted: Saturday , Jun 20, 2009 at 0118 hrs IST Related ArticlesMost Read Articles

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EXJADE ...

Che cos’è Exjade? Exjade is a
medicnale that contains the active substance deferasirox. It is available in the form of dispersible tablets round, whitish color, dissolved in a liquid such as water, form a suspension that the patient can drink. Each tablet contains 125 mg, 250 mg or 500 mg deferasirox. What
using Exjade?
Exjade is indicated for the treatment of a condition known as chronic iron overload (too much iron in the body), due to frequent blood transfusions. •

Exjade is used to reduce the amount of iron in the body of patients (older than six years) suffering from a hereditary disease called beta thalassemia major, for which treatment must undergo frequent blood transfusions. Patients with beta thalassemia major are unable to produce enough hemoglobin (the protein found in red blood cells that carries oxygen around the body) and therefore require frequent blood transfusions. For "frequent transfusions" means at least 7 ml of packed red blood cells per kilogram of body weight in a month. •

Exjade is indicated when treatment with DFO (another medicine used to treat chronic iron overload) is contraindicated or inadequate in patients suffering from other types anemia, children aged between two and five years and patients with beta thalassemia major who receive frequent transfusions.
Since the number of patients with chronic iron overload is low, the disease is rare. Exjade was designated an 'orphan medicine' (a medicine used in rare diseases) March 13, 2002.
The medicine can only be obtained with a prescription.

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here we go again ...

little time is true! but work commitments and often lead me to search elsewhere ... but they are always present and fight with you :-). I renew my commitment and my readiness to answer your questions, or even simple curiosity. I would like to open a trade on the new iron chelating drug: the EXJADE, if you want to have your say and we want to talk ... let's do it ... Greetings to all and see you soon ...